Sr. Director, Medical Director
Company: Fusion Pharmaceuticals
Location: Providence
Posted on: August 4, 2022
|
|
Job Description:
Fusion Pharmaceuticals is a clinical-stage oncology company
focused on developing next-generation radiopharmaceuticals as
precision medicines. Employing a proprietary Fast-Clear linker
technology, Fusion connects alpha particle emitting isotopes to
various targeting molecules in order to selectively deliver the
alpha emitting payloads to tumors.Fusion's lead program, FPI-1434
targeting insulin-like growth factor 1 receptor, is currently in a
Phase 1 clinical trial. The pipeline includes FPI-1966 targeting
the fibroblast growth factor receptor 3 (FGFR3) and FPI-2059, a
small molecule recently acquired from Ipsen, targeting neurotensin
receptor 1 (NTSR1). In addition to a robust proprietary pipeline,
Fusion has a collaboration with AstraZeneca to jointly develop up
to three novel targeted alpha therapies (TATs) and explore up to
five combination programs between Fusion's TATs and AstraZeneca's
DNA Damage Repair Inhibitors (DDRis) and immuno-oncology agents.
Fusion also entered into a collaboration with Merck to evaluate
FPI-1434 in combination with Merck's KEYTRUDA (pembrolizumab) in
patients with solid tumors expressing IGF-1R.The Medical Director
will report to the Head of Clinical Development and be responsible
for assisting with the advancement of specific radiopharmaceutical
oncology programs by devising clinical development strategies and
by serving as a representative for Clinical to project-specific
Development Teams. In addition, the Medical Director serves as the
Medical Monitor for ongoing clinical trials in assigned trials,
ensuring compliance with ICH/GCP and federal regulations.
Responsibilities: Provide Medical and Clinical Development
expertise and leadership to assigned clinical development
programsDesign and draft protocol synopses, clinical trial
protocols and protocol amendments, and contribute to various
regulatory documents, IBs, INDs and DSURsProvide medical oversight
of multiple clinical studies and provide medical input and guidance
on scientific, clinical and safety monitoring issuesPartner with
Clinical Operations and provide leadership and direction to
clinical project teamsEstablish and maintain positive relationships
with clinical trial investigators/physicians, KOLs and clinical
advisors through independent collaborations and scientific
meetingsProvide strategic input on compounds in development and
propose clinical development strategiesProvide medical expertise as
needed for business development initiativesProvide medical and
scientific expertise to preclinical discovery groups for compounds
that are in preclinical development Education and Skills
Requirements: MD, subspecialty training in oncology/hematology is
preferred3+ years of hands on pharmaceutical or biotech experience
in clinical development within OncologyExperience leading oncology
early clinical development programs and working with discovery,
preclinical, translational and external collaboratorsPrior
managerial experience including direct oversight of MDs and
Clinical Scientists is preferredIn-depth knowledge of the drug
development process and oversight of clinical trialsWorking
knowledge of biostatistics, regulatory requirements, clinical
pharmacology and pharmacokineticsPrior interaction with Regulatory
authorities and drafting of regulatory-related documentsPrior
experience developing radiopharmaceuticals and/or antibody drug
conjugates is a plusExcellent interpersonal, written, and verbal
communication skillsProven ability to successfully manage multiple
tasks and prioritize accordinglyProfessional and pleasant
demeanorThis is a Boston based positionWillingness to travel All
qualified applicants will receive consideration for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, national origin, disability, or status as a
protected veteran.
PDN-96755f54-3c45-4044-9dfe-c96cfb40d9db
Keywords: Fusion Pharmaceuticals, Providence , Sr. Director, Medical Director, Executive , Providence, Rhode Island
Click
here to apply!
|